个人简介
教授，长期从事微生物天然产物合成酶学、微生物药物合成、生物催化及丝状真菌合成生物学研究。先后主持国家自然科学基金项目3项、山东省人才项目1项，承担并完成企业合作项目一项。相关研究成果发表于J. Am. Chem. Soc.、Nat. Commun.、Metab. Eng.等国际知名期刊，累计发表论文20余篇。已申请发明专利 12 项，授权 3 项。
研究方向
1. 微生物天然产物生物合成及酶学机制
2. 丝状真菌代谢工程与合成生物学
3. 药用及工业酶的开发
4. 生物催化与药物先导化合物高效制造
学习与工作经历
2025/11-现在 山东科技大学化工与生物工程学院 教授
2014/08–2025/10 中国科学院青岛生物能源与过程研究所 博士后、助理研究员、副研究员
2024/05–2025/05 英国华威大学化学系 国家公派访问学者（CSC）
2010/09–2014/06 山东大学 微生物技术国家重点实验室，博士
2007/08–2010/09 鲁南制药集团，科研部
代表性论文（部分）
1. Feifei Qi, Wei Zhang, Yingying Xue, Ce Geng, Xuenian Huang, Jia Sun, Xuefeng Lu. Bienzyme-catalytic and dioxygenation-mediated anthraquinone ring opening. J. Am. Chem. Soc. 2021, 143 (40), 16326-16331
2. Feifei Qi#, Chao Lei#, Fengwei Li, Xingwang Zhang, Jin Wang, Wei Zhang, Zhen Fan, Weichao Li, Gong-Li Tang, Youli Xiao*, Guoping Zhao, Shengying Li*. Deciphering the late steps of rifamycin biosynthesis. Nat. Commun. 2018, 9, 2342.
3. Feifei Qi#; Wei Zhang#; Yingying Xue; Ce Geng; Zhigang Jin; Jibin Li; Qiang Guo; Xuenian Huang*; Xuefeng Lu*. Microbial production of the plant-derived fungicide physcion. Metab. Eng. 2022, 74, 130-138.
4. Yingying Xue#, Yajing Liang#, Wei Zhang, Ce Geng, Dandan Feng, Xuenian Huang, Sheng Dong, Yingfang Zhang, Jia Sun*, Feifei Qi*, Xuefeng Lu. Characterization and Structural Analysis of Emodin-O-Methyltransferase from Aspergillus terreus. J. Agric. Food Chem. 2022, 70 (18), 5728-5737.
5. Yongsong Wu#, Ning Xu#, Yingying Xue, Zilin Ren, Dan Liu, Xuenian Huang, Xuefeng Lu, Qiu Liu*, and Feifei Qi*, (2025). Mining UDP-Glucosyltransferases to Develop High-Efficiency Production Strategies for Emodin Glucosides. J. Agric. Food Chem. 2025, 10.1021/acs.jafc.5c03575.
6. Zilin Ren#, Yingying Xue#, Ning Xu., Dandan Feng., Ce Geng, Yongsong Wu, Dan Liu, Linshui Zhao, Xiaoxi Zhang, Honglei Ma, Xuenian Huang, Feifei Qi*, Xuefeng Lu*. Multi-Layered Engineering of Aspergillus terreus Enhances Biosynthesis of the Plant-Derived Fungicide Physcion. Microbial Cell Factories. 2025. 10.1186/s12934-025-02857-z
7. Feifei Qi, Weixin Zhang, Fengjie Zhang, Guanjun Chen，Weifeng Liu. Deciphering the effect of the different N-glycosylation sites on the secretion, activity and stability Of cellobiohydrolase I from Trichoderma reesei. Appl. Environ Microbiol. 2014，80（13）：3962~3971
8. Detao Wang, Yingying Xue, Yingfang Zhang, Hang Xun, Qirong Guo, Feng Tang, Jia Sun*, Feifei Qi*. Lignans and phenylpropanoids from the liquid juice of phyllostachys edulis. Nat. Prod. Res. 2019, 1
9. Ying Ye#, Lei Du#, Xingwang Zhang Sean A. Newmister, Morgan McCauley, Juan V. Alegre-Requena, Wei Zhang, Shuai Mu, Atsushi Minami, Amy E. Fraley, Maria L. Adrover-Castellano, Nolan A. Carney, Vikram V. Shende, Feifei Qi, Hideaki Oikawa, Hikaru Kato, Sachiko Tsukamoto, Robert S. Paton, Robert M. Williams*, David H. Sherman* Shengying Li*. Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nat. Catal. 2020, 3, 497-506
10. Wei Zhang, Lei Du, Zepeng Qu, Xingwang Zhang, Fengwei Li, Zhong Li, Feifei Qi, Xiao Wang, Yuanyuan Jiang, Ping Men, Jingran Sun, Shaona Cao, Ce Geng, Fengxia Qi, Xiaobo Wan, Changning Liu, Shengying Li. Compartmentalized biosynthesis of mycophenolic acid. Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 13305-13310
联系方式
办公室：J2-309
邮箱： skd995208@sdust.edu.cn
